"Touch and Teach"

Our "touch and teach" paradigm

The biological micro-universe is made of objects that do not belong to the field of our perceptions. 

Any researcher knows how important computer simulations are in revealing details of a molecular structure. Nevertheless, digital representation fails to reproduce a complete perceptive experience with the molecular object. Working for years in structural biology, we were looking for the nature of this lack, and we found that the only way to overcome the limits of digital representation is by “going back to the matter,” producing all the necessary plastic models for helping students and researchers involved in biochemistry and biology.

In a world that is always more virtualized, going back to touching matter could sound like a backstep. But what if we tell you that "touching" the micro with your hands is the only way to understand it deeply? Indeed, our slogan is “touch and teach,” which means “touch by yourself, explore and understand any physical details, and then explain to the others what you have understood.”


What does "foldomics" mean? 

Foldomics is a new scientific frontier. It's the science of studying how all the protein fold, with a unique glance at the implication in biology and medicine. Proteins are composed of amino acid chains, which need folding in a three-dimensional shape to accomplish their specific functions. Using multidisciplinary approaches combining experimental techniques, such as X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy, and computational modeling and simulation, foldomics investigate the impact of protein function in many fields like immunology, pharmacology, and diseases. 


Explore our micro-universe...

Combining Structure Biology with 3D printing technologies, we take snapshots of foldomics. Whenever the 3D structure of a protein is unknown, we use Machine Learning algorithms and Molecular Dynamics to predict the folding. The results are brilliant and powerfully informative.

In the transition from digital to analogic, Lunan Foldomics offers a unique perceptive experience of protein biology. 

Ideal for teachers and students and fundamental for research scientists, our models are fantastic puzzles for profoundly understanding the micro-universe!


Reproduction of 1E6 TCR in complex with HLA-A02 carrying "YQFGPDFPIA"

3D puzzle of TCR alpha and beta chains complexed with the HLA and antigen peptide. 

When dimerized, the two TCR chains (orange and blue) create an unique object, a receptor, which recognizes the antigen (red) presented by the MHC system (cyan and white) like a "key-lock" mechanism. 

For the case of the 1E6 receptor and its insulin antigen "YQFOPDFPIA", the recognition happens thanks to two strands of amino acids, "GDSSY" in the alpha chain and, "WEKLA", in the beta chain.

The two strands are both part of the Complementary-determining region 3 (green) located in the two TCR chains.

The central part of the antigen, containing a "GPD” sequence, represents the peptide’s fragment mainly recognized by GDSSY and WEKLA.


PDB: https://www.rcsb.org/structure/5c07

Creative Commons Attribution 4.0 International License


References:

D.K. Cole, A.M. Bulek, P.J. Rizkallah, and A.K. Sewel et al.: J Clin Invest 2016 Jun 1;126(6):2191-204. doi: 10.1172/JCI85679. Epub 2016 


HLA 02 complexed with Covid antigen

3D printing of structure of HLA-A*0201 complexed with peptide Md3-C9 derived from a clustering region of restricted cytotoxic T lymphocyte epitope from SARS-CoV M protein. 

PDB: https://www.rcsb.org/structure/3TO2


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